There are several effective anti-sickness medications that can be taken in pregnancy, if needed. Hyperemesis Gravidarum (HG) is usually worse in the first trimester and it is important medication is started without delay.Most effective medications for nausea and vomiting are not licensed in pregnancy. This does not mean the medication is unsafe or can’t be used. Taking medicine in pregnancy is about weighing the possible benefits of the medication with the possible risks of either taking the medication or leaving the person without treatment. It is important to remember that untreated HG can be dangerous for mum and baby so generally, the benefits of taking medication outweigh any possible risks.Taking more than one type at a time can be more effective. There isn’t a cure, but you should know within 48 hours if the medication that you have been prescribed is helping or not. If the medicine isn’t helping enough, then you can go back to your GP to talk about what other medicines you could try.